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CAS: N/A
Chemical Name: 2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N-(4-(4-(4-(5-((furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)piperazin-1-yl)butyl)acetamide
Purity: >98% (HPLC)
Novel cereblon-recruiting PRC1 bridged PROTAC degrader, inducing preferential degradation of PRC1 components, BMI1 and RING1B, in an EED-, CRBN-, and ubiquitin-proteosome system (UPS)-dependent manner
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00538
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