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CAS: 2439065-66-2
Chemical Name: N1,N1-Diethyl-N4-((3-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)methyl)pentane-1,4-diamine
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel CBP BrD inhibitor with an IC50 value of 744.3 nM, occupying the Kac-binding region firmly through hydrogen bonding with the conserved residue N1168, dose-dependently inhibiting the proliferation of human leukemia MV4-11 cells with an IC50 value of 19.2 μM and markedly downregulating the expression of the c-Myc in the cells
Reference:
https://www.nature.com/articles/s41401-019-0256-2
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