Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2409825-32-5
Chemical Name: (R)-2-(2-Chloro-5-(2-hydroxypropan-2-yl)-8-oxothieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazin-7(8H)-yl)-N-(1-methylpiperidin-3-yl)acetamide
Purity: >98% (HPLC)
Novel potent, orally bioavailable NLRP3 inhibitor, binding to the NLRP3 NACHT domain revealing a unique binding mode, demonstrating excellent potency in human whole blood and full inhibition of IL-1β release in a mouse acute peritonitis model at 30 mg/kg po dose
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c02098
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