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Glixx Laboratorie
CAS: N/A
Chemical Name: (4R)-N-[(1R)-1-[4-(Cyclopropylmethoxy)-6-oxopyran-2-yl]butyl]-2-[(Z)-N-hydroxy-C-methylcarbonimidoyl]-4-methyl-5H-1,3-thiazole-4-carboxamide
Purity: >98% (HPLC)
Novel potent tubulin inhibitor, targeting the entire colchicine binding domain of tubulin, covering four of the five centers of the pharmacophore model, showing high antitumor activity that efficiently overrides two resistance mechanisms in cells (detoxification pumps and tubulin βIII isotype overexpression)
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01775
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