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CAS: N/A
Chemical Name: A1APU; 10105-368-30-605; Cmpd 368; 2-(2-((1-(5-(Benzyloxy)pyridin-3-yl)naphthalen-2-yl)thio)acetamido)-3-(3-methoxy-4-methylphenyl)-N-methylpropanamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel inverse agonist negative allosteric modulator (NAM) for the the µ-opioid receptor (µOR), significantly inhibiting met-enkephalin induced µOR activation of Gi, resulting in inhibition of µOR-induced signaling when bound to a variety of orthosteric agonists
References:
https://www.biorxiv.org/content/10.1101/2023.09.08.556921v1.full
https://www.nature.com/articles/nature22354
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