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Glixx Laboratorie
CAS: N/A
Chemical Name: 1,1'-(((4-(7-Methoxy-2,3-dihydrobenzo[f][1,4]thiazepin-4(5H)-yl)butyl)azanediyl)bis(butane-4,1-diyl))bis(cyclopropan-1-ol)
Purity: >98% (HPLC)
Dual functional RyR2-stabilizing and SERCA2a-stimulating agent, preventing Ca2+ leak through ryanodine receptor 2 (RyR2) and enhancing cardiac sarco-endoplasmic reticulum (SR) Ca2+ load by activation of Ca2+-dependent ATPase 2a (SERCA2a), increasing ATP hydrolysis mediated by SERCA2a activity in cardiac microsomes, improving cardiac function in heart failure
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01235
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