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CAS: N/A
Chemical Name: 1-(2-(Dimethylamino)ethyl)-N-(4-(2-(1-(ethylsulfonyl)piperidin-4-yl)-4-(4-fluorophenyl)thiazol-5-yl)pyrimidin-2-yl)-1H-indol-5-amine
Purity: >98% (HPLC)
Novel fourth-generation EGFR inhibitor to overcome C797S-mediated resistance, showing potent inhibitory activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and significantly inhibited the proliferation of the H1975-TM cell line harboring EGFRL858R/T790M/C797S with an IC50 of 0.05 μM
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01165
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