Glixx Laboratories Inc
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Glixx Laboratorie
Chemical Name: FLT3/CHK1 inhibitor 18; 1-(6-((4-(((1s,4s)-4-Aminocyclohexyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-3,4-dihydroisoquinolin-2(1H)-yl)-3-hydroxy-3-methylbutan-1-one
Purity: >98% (HPLC)
Novel potent dual FLT3/CHK1 inhibitor, overcoming varying acquired resistance in BaF3 cells with FLT3-TKD and FLT3-ITD-TKD mutations, displaying high selectivity over c-KIT more than 1700-fold and greatly reducing hERG affinity, with an IC50 value of 58.4 μM
Reference:
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.3c00245
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