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CAS: N/A
Chemical Name: 2-((2-((2-(((((S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)carbonyl)oxy)ethyl)thio)propan-2-yl)thio)ethyl 5-((3aS,4R,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel SN-38 prodrug, significantly increasing up to 10-fold potency of SN-38 against NPC cell lines, showing specific binding to NPC via OppA-mediated recognition of surface heparan sulfate, being activated by tumor-associated biosignals to release SN-38
Reference:
https://www.nature.com/articles/s41467-024-48661-y
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