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Glixx Laboratorie
CAS: 2922732-54-3
Chemical Name: RM-036; (2S)-2-Cyclopentyl-2-((S)-7-((2R,3R)-3-cyclopropyl-1-methylaziridine-2-carbonyl)-2,7-diazaspiro[4.4]nonan-2-yl)-N-((22S,63S,4S)-12-(5-(4-cyclopropylpiperazin-1-yl)-2-((S)-1-methoxyethyl)pyridin-3-yl)-10,10-dimethyl-5,7-dioxo-11-(2,2,2-trifluoroethyl)-61,62,63,64,65,66-hexahydro-11H-8-oxa-2(4,2)-morpholina-1(5,3)-indola-6(1,3)-pyridazinacycloundecaphane-4-yl)acetamide
Purity: >98% (HPLC)
First-in-class, mutant-selective and orally bioavailable covalent tri-complex KRAS G12D(ON) inhibitor, inducing apoptosis and driving tumor regression in preclinical models of KRASG12D cancers
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