For Lab R&D Uses Only

Purity:               >98% (HPLC)

Product Description:

Novel potent and selective HDAC6 inhibitor, binding the HDAC6 catalytic domain 2 (K_i = 0.7 nM) and inhibiting enzyme function (IC₅₀ = 2 nM), exhibiting 158-fold selectivity for HDAC6 over other HDAC isozymes by binding the catalytic Zn²⁺ and, uniquely, making a never seen before, direct hydrogen bond with the Zn²⁺ coordinating residue, His614

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01922

Analytical data

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