Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2983719-82-8
Chemical Name: (Z)-(4-((2-Methoxy-5-(3,4,5-trimethoxystyryl)phenyl)amino)-4-oxobutanoyl)-L-arginine
Purity: >98% (HPLC)
Novel dual tubulin/NRP1 inhibitor (tubulin polymerization: IC50 = 0.71 ± 0.03 μM and NRP1: IC50 = 0.85 ± 0.04 μM), causing G2/M arrest and inducing cell apoptosis, suppressing cell tube formation, migration, and invasion, showing obvious antitumor effects on the PC-3 cell-derived xenograft model with negligible side effects and good pharmacokinetic profiles
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01572
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