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CAS: N/A
Chemical Name: (S,Z)-N-((2R,3R,5S,6S)-6-((2E,4E)-5-((3R,4R,5R)-4-Hydroxy-7,7-dimethyl-1,6-dioxaspiro[2.5]octan-5-yl)-3-methylpenta-2,4-dien-1-yl)-2,5-dimethyltetrahydro-2H-pyran-3-yl)-4-(methoxymethoxy)pent-2-enamide
Purity: >98% (HPLC)
Novel FR901464-based RNA splicing modulator, inducing alternative splicing of MCL-1, showing strong synergism with venetoclax in drug-resistant lung cancer cells, and being cancer-specific over normal cells
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00733
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