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CAS: N/A
Chemical Name: Ac-Pro-Arg-(Benzene-1,3-bismethylene)cyclo(Cys-Phe-Leu-Val-Met)-Lys-Pro-Arg-Arg-Arg-Arg-Trp-NH2 Bromide
Purity: >98% (HPLC)
Novel covalent peptide LSD1 inhibitor, specifically recognizing Cys360 in the enzyme-active region, inhibiting LSD1 activity, increasing H3K4me1 and H3K4me2 levels, leading to G1 cell cycle arrest and apoptosis and inhibiting cell proliferation
Reference
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01549
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