Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2378780-25-5
Chemical Name: N-(3-(Diethylamino)propyl)-5-((4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide
Purity: >98% (HPLC)
Novel potent and selective Nur77 antagonist against triple-negative breast cancer (TNBC) cell lines without inhibiting human normal breast cancer cell line MCF-10A (SI > 20), Nur77-dependently causing mitochondria dysfunction and inducing the caspase-dependent apoptosis by mediating the TP53 phosphorylation pathway
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01336
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