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Nur77 antagonist Ja

 

CAS: 2378780-25-5

 

Chemical Name: N-(3-(Diethylamino)propyl)-5-((4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide

 

 
GLXC-27889For Lab R&D Uses Only
        Cat No: GLXC-27889

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel potent and selective Nur77 antagonist against triple-negative breast cancer (TNBC) cell lines without inhibiting human normal breast cancer cell line MCF-10A (SI > 20), Nur77-dependently causing mitochondria dysfunction and inducing the caspase-dependent apoptosis by mediating the TP53 phosphorylation pathway

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01336

 

Analytical data click for PDF file

 

 

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