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CAS: N/A
Chemical Name: (E)-N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide
Purity: >98% (HPLC)
Novel PDEδ autophagic degrader, exhibiting potent PDEδ binding affinity and efficiently inducing PDEδ degradation in a concentration-dependent manner, being much more effective in suppressing the growth in KRAS mutant pancreatic cancer cells than the corresponding PDEδ inhibitor
Reference:
https://pubs.acs.org/doi/10.1021/acsmedchemlett.3c00161
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