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CAS: 2893809-51-1
Chemical Name: 4-((R)-4-((2S,5R)-4-Acryloyl-2,5-dimethylpiperazin-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-6-(trifluoromethyl)quinazolin-7-yl)-2-amino-7-fluorobenzo[b]thiophene-3-carbonitrile
Purity: >98% (HPLC)
First-in-class, direct inhibitor of KRASG12C (ON), locking GTP-bound KRASG12C in the state 1 conformation resulting in rapid and blocking effector binding
References:
https://link.springer.com/article/10.1007/s40265-023-01980-8
https://aacrjournals.org/cancerres/article/84/7_Supplement/ND07/742758
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