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CAS: N/A
Chemical Name: N1-(3-(2-Chloro-N-((R)-1,1-dioxidotetrahydrothiophen-3-yl)acetamido)-2,2-dimethylpropyl)-N4-(12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)dodecyl)succinamide
Purity: >98% (HPLC)
First-in-class and potent PROTAC degrader of Pin1, inducing Pin1 degradation with a DC50 value of 177 nM and exhibiting potent degradation-dependent anti-proliferative activities in a panel of acute myeloid leukemia (AML) cell lines, up-regulating ROS pathway and down-regulating UPR pathway to induce cell DNA damage and apoptosis
Reference:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10967256/
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