Glixx Laboratories Inc

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Glixx Laboratorie

 

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P1D-34

 

CAS: N/A

 

Chemical Name: N1-(3-(2-Chloro-N-((R)-1,1-dioxidotetrahydrothiophen-3-yl)acetamido)-2,2-dimethylpropyl)-N4-(12-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)dodecyl)succinamide

 

 
GLXC-28461For Lab R&D Uses Only
        Cat No: GLXC-28461

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

First-in-class and potent PROTAC degrader of Pin1, inducing Pin1 degradation with a DC50 value of 177 nM and exhibiting potent degradation-dependent anti-proliferative activities in a panel of acute myeloid leukemia (AML) cell lines, up-regulating ROS pathway and down-regulating UPR pathway to induce cell DNA damage and apoptosis

 

Reference:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10967256/

 

Analytical data click for PDF file

 

 

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