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CAS: N/A
Chemical Name: (R)-N-(3-((4-(2-(2-((3-(N-(1-(3-Benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamido)propyl)amino)-2-oxoethoxy)ethyl)piperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)-4-ethyl-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzamide
Purity: >98% (HPLC)
Novel discoidin domain receptor 1 (DDR1) degrader (DC50 value of 150.8 nM), inducing DDR1 degradation via lysosome-mediated autophagy, potently suppressing cancer cell tumorigenicity, migration, and invasion
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00162
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