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JAB-3312

 

CAS: 2245082-05-5

 

Chemical Name: (S)-1'-(5-((2-Amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,4'-piperidin]-5-amine

 

 
GLXC-28835For Lab R&D Uses Only
        Cat No: GLXC-28835

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel potent SHP2 allosteric inhibitor for cancer treatment, exhibiting a SHP2 binding Kd of 0.37 nM, SHP2 enzymatic IC50 of 1.9 nM, KYSE-520 antiproliferative IC50 of 7.4 nM and p-ERK inhibitory IC50 of 0.23 nM

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00360

 

Analytical data click for PDF file

 

 

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