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CAS: 2245082-05-5
Chemical Name: (S)-1'-(5-((2-Amino-3-chloropyridin-4-yl)thio)pyrazin-2-yl)-5,7-dihydrospiro[cyclopenta[b]pyridine-6,4'-piperidin]-5-amine
Purity: >98% (HPLC)
Novel potent SHP2 allosteric inhibitor for cancer treatment, exhibiting a SHP2 binding Kd of 0.37 nM, SHP2 enzymatic IC50 of 1.9 nM, KYSE-520 antiproliferative IC50 of 7.4 nM and p-ERK inhibitory IC50 of 0.23 nM
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00360
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