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Glixx Laboratorie
CAS: N/A
Chemical Name: (2S,3R,4S,5R,6R)-2-((1,3,2-Dithiarsolan-2-yl)thio)-6-(acetoxymethyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
Purity: >98% (HPLC)
Novel P53-targeting arsenical with potent cellular uptake and cancer cell selectivity, exhibiting remarkable cellular uptake through a thiol-mediated pathway (maximally 127-fold higher than arsenic trioxide), thereby potently targeting PML/RARα and mutant p53
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00104
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