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CAS: N/A
Chemical Name: N-Butyl-3-((4aS,4bR,7S,8aR,10aR)-7-hydroxy-2,4b,8,8-tetramethyl-3,4,4a,4b,5,6,7,8,8a,9,10,10a-dodecahydrophenanthren-1-yl)propanamide
Purity: >98% (HPLC)
Novel hedgehog (Hh) signaling suppressor, blocking the cholesterylation of cysteine-rich domain (CRD) of smoothened (SMO), inhibiting the drug-resistant and oncogenic SMO variants and Hh-dependent medulloblastoma growth
Reference:
https://www.cell.com/cell-chemical-biology/abstract/S2451-9456(24)00076-X
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