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Glixx Laboratorie
CAS: 3032451-66-1
Chemical Name: 4-(3-(3-(5-Bromofuran-2-yl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
Purity: >98% (HPLC)
New-generation antiresistant PARP inhibitor, exhibiting distinct antiproliferation activity against olaparib- and talazoparib-resistant cells, with IC50 values of 0.89 and 1.13 nM, respectively, retaining sensitivity in drug-resistant cells with BRCA1/2 restoration or 53BP1 loss
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00821
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