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Glixx Laboratorie
CAS: 2978521-26-3
Chemical Name: (2S,4R)-N-((S)-5-Amino-5-oxopent-1-yn-3-yl)-4-fluoro-1-(1-(4-(trifluoromethoxy)phenyl)cyclopropane-1-carbonyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
The first orthosteric, selective, orally bioavailable, irreversible, and brain penetrant inhibitor of asparagine endopeptidase (AEP), reducing Tau N368 fragment both in vitro and in vivo
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01804
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