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CAS: N/A
Chemical Name: (2S,4R)-1-((S)-2-(12-(4-(4-((2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butanamido)dodecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: >98% (HPLC)
First-in-Class selective G9a/GLP PROTAC degrader, inducing G9a/GLP degradation in a concentration-, time-, and ubiquitin-proteasome system (UPS)-dependent manner
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c02394
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