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Glixx Laboratorie
CAS: 2340388-72-7
Chemical Name: N-Cyclopropyl-2-(difluoromethoxy)-6-methoxy-4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)benzamide
Purity: >98% (HPLC)
Novel potent and selective pan-SIK inhibitor (IC50: 2.0 nM for SIK1, 0.7 nM for SIK2, and 0.6 nM for SIK3), demonstrated both anti-inflammatory and immunoregulatory activities in vitro in human primary myeloid cells and in vivo in mouse models
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01428
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