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CAS: N/A
Chemical Name: TCO-MZ1; (3R,5S)-1-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)-5-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-3-yl ((E)-cyclooct-2-en-1-yl) carbonate
Purity: >98% (HPLC)
Novel highly reactive trans-cyclooctene (TCO)-containg PROTAC MZ1 to be able to be activated by highly active tetrazine compound, such as IR808-TZ (GLXC-27850)
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01423
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