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CAS: N/A
Chemical Name: KTD606; K252a dimer; (5S,5'S,7R,7'R,8S,8'S)-13,13'-(Heptane-1,7-diyl)bis(7-hydroxy-8-methyl-15-oxo-5,6,7,8,14,15-hexahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-7-carboxylic acid)
Purity: >98% (HPLC)
Selective inhibitor of Rac/CDC42-dependent kinases (PAKs) or mixed-lineage kinases (MLK) both in vitro and in cell culture, converting v-Ha-RAS-transformed NIH 3T3 cells to flat fibroblasts similar to the parental normal cells.
References:
https://onlinelibrary.wiley.com/doi/10.1111/j.1472-8206.2008.00614.x
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