Glixx Laboratories Inc
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Chemical Name: 4-((2-(4-(1-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity: >98% (HPLC)
Novel Brigatinib PROTAC degrader, degrading not only ALK fusion proteins in activating G1202R-mutated form but also mutant EGFR with L858R + T790M as well as several important oncoproteins involved in metastasis such as FAK, PYK2, and PTK6, strongly inhibiting cell migration and invasion of Calu-1 and MDA-MB-231
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