Glixx Laboratories Inc

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SIAIS164018

 

CAS: N/A

 

Chemical Name: 4-((2-(4-(1-(4-((5-Chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

 

 
GLXC-24147For Lab R&D Uses Only
        Cat No: GLXC-24147

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel Brigatinib PROTAC degrader, degrading not only ALK fusion proteins in activating G1202R-mutated form but also mutant EGFR with L858R + T790M as well as several important oncoproteins involved in metastasis such as FAK, PYK2, and PTK6, strongly inhibiting cell migration and invasion of Calu-1 and MDA-MB-231

 

Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00373

 

Analytical data click for PDF file

 

 

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