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CAS: N/A
Chemical Name: N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-4-methyl-6-oxo-1-(p-tolyl)-1,6-dihydropyridazine-3-carboxamide
Purity: >98% (HPLC)
Novel JNK2 inhibitor, decreasing the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC50 = 0.22 μM), demonstrating remarkable protection against acute lung injury (ALI) and sepsis by targeting JNK2 and inhibiting the JNK2-NF-κB/MAPK pathway
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00832
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