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Glixx Laboratorie
CAS: 2409479-29-2 (racemic: 2101925-20-4)
Chemical Name: 1-(4-{(1R)-1-[2-({6-[6-(Dimethylamino)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]ethyl}piperazin-1-yl)-3,3,3-trifluoropropan-1-one
Purity: >98% (HPLC)
Novel potent and highly selective TBK1/Ikkε inhibitor, inhibiting the cellular phosphorylation of interferon regulatory factor 3 (IRF3) and displaying antiproliferative efficacy in the melanoma cell line SK-MEL-2, but showing only weak to moderate antitumor activity in the SK-MEL-2 human melanoma xenograft model
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01460
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