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CAS: N/A
Chemical Name: CuB derivative A11; (2S,8S,9R,10R,13R,14S,16R,17R)-17-((S,E)-6-Acetoxy-2-hydroxy-6-methyl-3-oxohept-4-en-2-yl)-16-hydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl 2-(4-(4-fluorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetate
Purity: >98% (HPLC)
Novel cucurbitacin B (CuB) derivative, targeting IGF2BP1 against non-small cell lung cancer, being approximately 10-fold more potent than CuB, while its cytotoxicity about 10-fold less potent, also having a much wider therapeutic window than CuB
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00872
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