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CAS: N/A
Chemical Name: HDAC8 PROTAC BP6; 1-(4-((1-(2-(2-(2-(2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetamido)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)-N-hydroxy-1H-indole-6-carboxamide
For Lab R&D Uses Only
Purity: >98% (HPLC)
Novel HDAC8 degrader (DC50, 24 h = 81 nM, Dmax, 24 h = 93%), enhancing the tumor suppressor p53 stability, thereby significantly increasing the sensitivity of leukemia cells to the MDM2 antagonist idasanutlin (GLXC-90214) than PCI-34051 (GLXC-90446)
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c00939
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