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Glixx Laboratorie
CAS: 2499962-58-0
Chemical Name: (R)-N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-6-(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Purity: >98% (HPLC)
Novel potent activator of PINK1, binding PINK1 directly, stabilizing it in an active conformation, and clearing mitochondrial aggregates via PINK1-dependent mitophagy in cells and decreased ubiquitin phosphorylation in the brain and plasma from PD animal models
Reference:
https://www.biorxiv.org/content/10.1101/2023.02.14.528378v2
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