For Lab R&D Uses Only

Purity:               >98% (HPLC)

Product Description:

Novel hydrophobic tagging-based ALK degrader, achieving effective degradation of the EML4-ALK fusion protein in H3122 cells with CRBN expression knocked down via siRNA, significantly suppressing tumor growth with moderate oral bioavailability, effectively targeting ALK through the Hsp70 chaperone system and the ubiquitin-proteasome pathway

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c00488

Analytical data

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