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SHP2-D26

 

CAS: 2458219-65-1

 

Chemical Name: SHP-D26; (2S,4R)-1-((R)-2-(9-(4-(4-((3-((3-Amino-5-(4-amino-4-methylpiperidin-1-yl)pyrazin-2-yl)thio)-2-chlorophenyl)amino)-4-oxobutanoyl)piperazin-1-yl)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((R)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

 

 
GLXC-22598For Lab R&D Uses Only
        Cat No: GLXC-22598

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

First, Potent, and Effective PROTAC Degrader of SHP2 Protein, being is >30-times more potent in inhibition of phosphorylation of extracellular signal-regulated kinase (ERK) and of cell growth than SHP099, a potent SHP2 inhibitor, in KYSE520 and MV4;11 cancer cell lines

 

References:

https://pubmed.ncbi.nlm.nih.gov/?term=SHP2-D26&sort=date

 

Analytical data click for PDF file

 

 

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