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CAS: N/A
Chemical Name: 1-(3-(2-Ethoxyethoxy)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2-(trifluoromethyl)-1H-benzo[d]imidazole-5-carboxylic acid
For Lab R&D Uses Only
Purity: >98% (HPLC)
The first "Gatekeeper" RXR antagonist that does not show allosteric inhibition in permissive RXR heterodimers, binding domain (LBD) at the entrance of the ligand binding pocket (LBP), blocking access to the LBP and thus serving as a "gatekeeper"
Ref: https://pubs.acs.org/doi/10.1021/acs.jmedchem.0c01354
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