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CAS: 1029227-48-2
Chemical Name: N-{(2S)-2-[(N,N-Dimethyl-L-valyl)oxy]-3-methylbutanoyl}-N,O-dimethyl-L-seryl-N-[(3S,6S,9S,12S,15S,18S,21S,22R)-15-[(2S)-2-butanyl]-9-isobutyl-6-(4-methoxybenzyl)-18-(methoxymethyl)-3,4,10,12,16,19,22- ;heptamethyl-2,5,8,11,14,17,20-heptaoxo-1-oxa-4,7,10,13,16,19-hexaazacyclodocosan-21-yl]-N,N2-dimethyl-L-leucinamide
Purity: >98% (HPLC)
Natural lariat depsipeptide, inhibiting VEGFA/VEGFR2 expression and suppressing tumor growth in glioblastoma xenografts, targeting Sec61 to prevent biogenesis of secretory and membrane proteins
References:
1) https://pubs.acs.org/doi/10.1021/acschembio.0c00325
2) https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01141
3) https://www.mdpi.com/1660-3397/16/3/77
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