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Glixx Laboratorie
CAS: 34374-22-6
Chemical Name: N-((3-Chloro-8-methoxy-11H-indolo[3,2-c]quinolin-9-yl)methyl)-N-ethylethanamine
Purity: >98% (HPLC)
First-in-class selective inhibitor of the PP1β:MYPT1 holoenzyme, binding directly to the Ank domain of MYPT1, inhibiting the PP1β:MYPT-(1-314)KAKA sensor with an average IC50 of 18 μM, not affecting the PP1β:MYPT1WT and PP1α:I2SAKA sensors
Reference:
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00242-8
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