For Lab R&D Uses Only

Purity:               >98% (HPLC)

Product Description:

Novel human caseinolytic protease P (HsClpP) agonist for the treatment of hepatocellular carcinoma, exhibiting potent HsClpP agonistic activity in the α-casein hydrolysis assay (EC₅₀ = 1.30 μM) and inhibiting the proliferation of HCCLM3 cells (IC₅₀ = 3.1 μM, 21.4-fold higher than hit ADX-47273), inducing degradation of respiratory chain complex subunits and leading to apoptosis in HCC cells, having potent tumor growth inhibitory activity and a superior safety profile compared to the kinase inhibitor sorafenib

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00080

Analytical data

Price & Availability