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4-Octyl Itaconate


CAS: 3133-16-2


Chemical Name: 4-OI; 2-Methylidene-4-octoxy-4-oxobutanoic acid


GLXC-22752For Lab R&D Uses Only
        Cat No: GLXC-22752


Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)



Product Description:

Selective inhibitor of NLRP3 inflammasome activation, inhibiting the interaction between NLRP3 and NEK7, a key step in the activation process, and "dicarboxypropylated" C548 on NLRP3, also inhibiting NLRP3-dependent IL-1β release from PBMCs isolated from cryopyrin-associated periodic syndrome (CAPS) patients, and reduced inflammation in an in vivo model of urate-induced peritonitis







Analytical data click for PDF file



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