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CAS: N/A
Chemical Name: MLKL degrader 36; 3-(4-((Difluoromethyl)sulfonamido)phenyl)-5-((3-((8-(9-(3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoyl)-3,9-diazaspiro[5.5]undecan-3-yl)-8-oxooctyl)oxy)phenyl)amino)-1H-pyrazole-4-carboxamide
Purity: >98% (HPLC)
Novel potent MLKL PROTAC, effectively degrading MLKL (Dmax >90%) and completely abrogating cell death in a TSZ model of necroptosis (Emax TSZ 100%), protecting cells from necroptosis
Reference:
https://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.3c00665
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