Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 1443235-95-7
Chemical Name: Ethyl 4-(3-methacrylamidophenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
Purity: >98% (HPLC)
Nove potent and highly selective covalent inhibitor of JAK3, being 4300-fold selective for JAK3 over JAK1 in enzyme assays, 67-fold [interleukin (IL)-2 versus IL-6] or 140-fold [IL-2 versus erythropoietin or granulocyte-macrophage colony-stimulating factor (GMCSF)] selective in cellular reporter assays and >35-fold selective in human peripheral blood mononuclear cell assays (IL-7 versus IL-6 or GMCSF)
Ref: https://jpet.aspetjournals.org/content/361/2/229.long
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