Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 1361227-90-8
Chemical Name: 8-Chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methylbutanoyl)-5-nitro-4(1H)-quinolinone
Purity: >98% (HPLC)
Novel inhibitor of mutagenic translesion synthesis (TLS), disrupting mutagenic TLS by preventing recruitment of mutagenic POL ζ, targets a nearly featureless surface of REV1 that interacts with the REV7 subunit of POL ζ, inducing REV1 dimerization to block the REV1-REV7 interaction
Ref: https://www.cell.com/cell/pdf/S0092-8674(19)30556-2.pdf
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