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CAS: N/A
Chemical Name: 4-(2-Ethylbutyl)-N-(3-(4-fluorophenoxy)-5-(4-(methylcarbamoyl)phenoxy)phenyl)piperazine-1-carboxamide
Purity: >98% (HPLC)
Novel S1PR2 Antagonist, potently interacting with S1PR2 with a KD value of 0.73 nM, displaying potent 5-FU resensitizing activity in multiple 5-FU-resistant tumor cell lines, particularly in SW620/5-FU (EC50 = 1.99 ± 0.03 μM) but shows no cytotoxicity in the normal colon cell line NCM460 up to 1000 μM
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00958
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