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S1PR2 Antagonist 43

 

CAS: N/A

 

Chemical Name: 4-(2-Ethylbutyl)-N-(3-(4-fluorophenoxy)-5-(4-(methylcarbamoyl)phenoxy)phenyl)piperazine-1-carboxamide

 

 
GLXC-26432For Lab R&D Uses Only
        Cat No: GLXC-26432

 

Purity:               >98% (HPLC)

Storage:             Refrigerator (4 °C)

 

 

Product Description:

Novel S1PR2 Antagonist, potently interacting with S1PR2 with a KD value of 0.73 nM, displaying potent 5-FU resensitizing activity in multiple 5-FU-resistant tumor cell lines, particularly in SW620/5-FU (EC50 = 1.99 ± 0.03 μM) but shows no cytotoxicity in the normal colon cell line NCM460 up to 1000 μM

 

Reference:

https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c00958

 

Analytical data click for PDF file

 

 

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