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 PF-06651600 malonate

 

CAS: 2140301-97-7 (free base: 1792180-81-4)

 

Chemical Name: Ritlecitinib malonate; 1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-piperidin-1-yl]-propenone malonate

 

 

GLXC-09605        Cat No: GLXC-09605

 

 

Purity:               > 98% (HPLC)

Storage:             Refrigerator (4 °C)

 


Product Description:

Npvel potent JAK3-selective inhibitor, selectively targeting garmma-c cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling such as the IL-10 suppressive functions following LPS treatment in macrophages and the suppression of TNFa and IL-1ß production in IL-27-primed macrophages

 

References:

1) https://onlinelibrary.wiley.com/doi/10.1002/art.41316

2) https://pubs.acs.org/doi/10.1021/acschembio.9b00188

3) https://www.nature.com/articles/mi201738


 

Analytical data click for PDF file

 

 

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