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CAS: 2946593-46-8
Chemical Name: (1R,6R)-3-(7-(8-Chloronaphthalen-1-yl)-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)-8-oxa-3-azabicyclo[4.2.0]octan-7-one
Purity: >98% (HPLC)
Novel potent covalent K-RasG12S inhibitor, exhibiting both improved reversible binding affinity (Ki = 26 µM) and an accelerated reaction (kinact = 6.4 min−1) with K-RasG12S
Reference:
https://www.nature.com/articles/s41589-022-01065-9
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