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CAS: N/A
Chemical Name: 5-(3-((4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)methyl)azetidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity: >98% (HPLC)
Novel degrader of oncogenic EML4-ALK fusions, avoiding hemolysis (a feature of detergent-like PROTACs), degrading the otherwise recalcitrant mutant L1196M/G1202R in vivo, and commensurately slowing tumor growth
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01864
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