Glixx Laboratories Inc
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Glixx Laboratorie
CAS: 2852050‑29‑2
Chemical Name: 5'-Acrylamido-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2',4-dimethyl-[1,1'-biphenyl]-3-carboxamide
Purity: >98% (HPLC)
Novel potent and selective EZH2 covalent inhibitor, bindpng to the S-adenosylmethionine (SAM) pocket of EZH2, being highly potent for EZH2MUT, while exhibiting weak activities against other tested histone methyltransferases (HMTs) and kinases
Reference:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01370
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