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Glixx Laboratorie
CAS: 748142-06-5
Chemical Name: N-(4-Isopropylphenyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine
Purity: >98% (HPLC)
Novel potent inhibitor of CDK8, CDK19, and CDK9 with IC50 at 1.05, 2.67, and 19.9 nM, respectively, causing MYC loss through both transcriptional and posttranslational mechanisms, and suppressing PDAC anchorage-dependent and anchorage-independent growth, inducing the substantial loss of MYC protein in both two-dimensional (2D) and 3D cell cultures
Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728149/
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